Progesterone refining method

The present invention relates to a progesterone refining method, which can improve the product quality, and comprises: adding a progesterone crude product into a reaction vessel, adding a reaction solvent into the reaction vessel, uniformly stirring, adding an impurity removing agent, and stirring to obtain a first reaction system; performing vacuum concentration on the first reaction system to obtain a concentrated system with the content of the reaction solvent being lower than 10%; adding a dissolving solvent and water into the concentration system, stirring for dissolving, and slowly adding an acid solution to obtain a second reaction system; standing the second reaction system to obtain a liquid-liquid layering system consisting of an organic phase and a water phase, and extracting the organic phase from the liquid-liquid layering system; concentrating the organic phase under reduced pressure until the content of the dissolving solvent in the organic phase is lower than 40%, and then adding a crystalliza