Preparation method of NH-1, 2, 3-triazole compound

The invention provides a preparation method of an NH-1, 2, 3-triazole compound. The preparation method comprises the steps of carrying out cycloaddition reaction on a first dispersion liquid containing sodium azide, an aldehyde compound, a first acid and an alkyne compound under the action of a cata...

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Hauptverfasser: XIONG ZHENGCHANG, YUAN QINGQING, LI BINBIN, JIAO JIANYE, TAO ZIPENG, FU XUFEI, HONG HAO, XIAO YI, WANG FEIGE, DONG CHANGMING, WANG GUOHUAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a preparation method of an NH-1, 2, 3-triazole compound. The preparation method comprises the steps of carrying out cycloaddition reaction on a first dispersion liquid containing sodium azide, an aldehyde compound, a first acid and an alkyne compound under the action of a catalyst to generate an intermediate product A; and carrying out elimination reaction on the intermediate product A under the action of second acid or alkali to generate the NH-1, 2, 3-triazole compound. Based on the synthetic route, the method has the advantages that the raw materials are cheap and easier to obtain, the operation is simpler and more convenient, the reaction efficiency is higher, the process is more controllable, the safety is higher, the energy consumption is lower, the three wastes are less, the comprehensive cost is lower, the production is easier to amplify, and the like. 本发明提供了一种NH-1,2,3-三氮唑类化合物的制备方法。该制备方法包括:使包含叠氮钠、醛基化合物、第一酸及炔烃化合物的第一分散液在催化剂的作用下进行环加成反应,生成中间产物A;使中间产物A在第二酸或碱的作用下进行消除反应,生成NH-1,2,3-三氮唑类