MINI SOFTGEL NAPROXEN COMPOSITION

Disclosed herein are mini softgel capsules comprising a reaction product of naproxen free acid and potassium hydroxide in a molar ratio of potassium hydroxide to naproxen free acid of less than about 1. Also disclosed herein are methods for treating patients in need thereof with the mini softgel cap...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser:	SHELLEY RICKEY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Disclosed herein are mini softgel capsules comprising a reaction product of naproxen free acid and potassium hydroxide in a molar ratio of potassium hydroxide to naproxen free acid of less than about 1. Also disclosed herein are methods for treating patients in need thereof with the mini softgel capsules as well as methods for stabilizing mini softgel capsules that include a fill composition that has a high concentration of active agent. 本文公开了包含萘普生游离酸和氢氧化钾的反应产物的微型软胶囊，其中氢氧化钾与萘普生游离酸的摩尔比小于约1。本文还公开了使用微型软胶囊治疗有此需要的患者的方法以及用于稳定包括具有高浓度活性剂的填充组合物的微型软胶囊的方法。