Tricyclic pyrimidine derivative and application

The invention relates to a tricyclic pyrimidone derivative and application thereof. According to the derivatives, six compounds such as A1, A2, B1, B2, C1, C2, D1 and D2 are used as initial raw materials, and corresponding 36 derivatives such as E1-E10, F1-F10, G1-G10 and H1-H6 are obtained through reactions such as condensation and halogenation. DOX is used as a positive control; the inhibitory activity of the 36 compounds on HeLa cervical cancer cells, MCF-7 breast cancer cells and HT-29 human colon cancer cells is investigated, and the result shows that 7 compounds have the inhibitory activity on the HeLa cervical cancer cells; 2 compounds have inhibitory activity on MCF-7 breast cancer cells; 10 compounds have inhibitory activity on HT-29 human colon cancer cells; E2, E3, F3, F5, H1, H5 and H6 have inhibitory activity on HeLa cervical cancer cells; H1 and H2 have inhibitory activity on MCF-7 breast cancer cells; and E2, E3, F5, G1, G6, G7, H1, H3, H5 and H6 have inhibitory activity on HT-29 human colon ca