3-chloromethyl-1-azabicyclo[2.2.2]octane hydrochloride and preparation method thereof

The invention discloses 3-chloromethyl-1-azabicyclo[2.2.2]octane hydrochloride and a preparation method thereof. The method comprises the following steps of 1, subjecting a Grignard reagent and 3-quininone to a reaction to obtain a product I; 2, reacting the product I with thionyl chloride to obtain a product II; and 3, carrying out hydrogenation reaction on the product II in the presence of a catalyst to obtain CMAO, and treating the CMAO to obtain CMAO.HCl. The invention provides a new method for synthesizing CMAO.HCl, and provides a thought for performing chloromethylation on alkane containing ketone and aldehyde carbonyl groups and an aromatic hydrocarbon compound at the alpha position of the carbonyl groups by using halochloromethane, and the method provided by the invention has the advantages of simple synthetic route, easily available raw materials, economy, safety and high total yield, and is suitable for large-scale production. 本发明公开了一种3-氯甲基-1-氮杂双环[2.2.2]辛烷盐酸盐及其制备方法，所述方法包括以下步骤：步骤1、将格氏试剂与3-奎宁酮进行反应，获得产