Ticagrelor related substance I and preparation method thereof

The invention discloses a ticagrelor related substance I and a preparation method thereof, and belongs to the field of organic synthetic pharmaceutical chemistry. The related substance I is 2-(((3aR, 4S, 6R, 6aS)-6-(7-((1R, 2S)-2-(3, 4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolyl[4,5-d]pyrimidine-3-yl)-2,2-dimethyl tetrahydro-4H-cyclopentyl[d][1,3]dioxo-4-oxyl)ethyl nitrite is used as raw material for preparing compound., and the structural formula of the related substance I is shown in the specification. The preparation method is simple, raw materials are easy to obtain, reaction conditions are mild, and the safety coefficient is high. The related substance I is high in purity, and the method is high in operability, easy to operate in a laboratory and beneficial to research of impurity standard substances. 本发明公开了一种替格瑞洛有关物质I及其制备方法，属于有机合成药物化学领域。所述有关物质I为2-(((3aR，4S，6R，6aS)-6-(7-((1R，2S)-2-(3,4-二氟苯基)环丙基)氨基)-5-(丙基硫基)-3H-[1,2,3]三唑基[4,5-d]嘧啶-3-基)-2,2-二甲基四氢-4H-环戊基[d][1,3]二氧基-4-氧基)亚硝酸乙酯，其结构式如下