Degradable drug sustained-release material and preparation method thereof

The invention discloses a degradable drug sustained-release material. The degradable drug sustained-release material comprises amphiphilic chitosan, polyanhydride and a drug. The preparation method of the degradable drug sustained-release material comprises the following steps: 1) preparing amphiphilic chitosan; 2) preparing polyanhydride; 3) preparing the degradable drug sustained-release material. According to the degradable drug sustained-release material provided by the invention, the sustained-release control of the drug can be realized by utilizing the surface corrosion degradation performance of the polyanhydride; herein, the alkyl chains are connected to amino groups, so that the distance between the amino groups is increased, the hydrogen-bond interaction is weakened, a part of amino groups can be replaced, and the number of hydrogen bonds is reduced, so that the crystallinity of chitosan can be weakened, the solubility can be enhanced, and the modified chitosan has amphiphilic performance; besides,