Chimeric antigen recipient cell targeting human Claudin18.2 and NKG2DL and preparation method and use thereof

The invention belongs to the field of chimeric antigen recipient cells and relates to a chimeric antigen recipient cell targeting human Claudin18.2 and NKG2DL and a preparation method and use thereof. The chimeric antigen recipient cell contains amino acid sequences targeting and binding human Claud...

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Bibliographische Detailangaben
Hauptverfasser:	XU HUI, DAI HONGJIU, ZHU LIANGJING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention belongs to the field of chimeric antigen recipient cells and relates to a chimeric antigen recipient cell targeting human Claudin18.2 and NKG2DL and a preparation method and use thereof. The chimeric antigen recipient cell contains amino acid sequences targeting and binding human Claudin18.2 and human NKG2DL. An immune response cell modified by a bispecific chimeric antigen receptor targeting Claudin18.2 and NKG2DL can enhance binding with tumor cells and obviously improves anti-tumor activity. 本发明属于嵌合抗原受体细胞领域，一种靶向人Claudin18.2和NKG2DL的嵌合抗原受体细胞及其制备方法和应用,该嵌合抗原受体细胞含有靶向结合人Claudin18.2和靶向结合人NKG2DL的氨基酸序列。本发明的靶向Claudin18.2和NKG2DL的双特异性嵌合抗原受体修饰的免疫应答细胞能增强与肿瘤细胞的结合，明显提高抗肿瘤活性。