Two-phase oil adjuvant foot-and-mouth disease vaccine stabilizer and application thereof

The invention discloses a two-phase oil adjuvant foot-and-mouth disease vaccine stabilizer and application thereof The two-phase oil adjuvant foot-and-mouth disease vaccine stabilizer is prepared from the following components in percentage by weight of 0.1 to 1 percent of acid, 0.1 to 2 percent of alcohol, 0.1 to 2 percent of amine, 0.1 to 10 percent of charge control agent, 0.1 to 15 percent of polymer, 0.1 to 20 percent of sugar and the balance of water. The stabilizer provided by the invention improves the preservation effect, immune efficacy and safety level of the two-phase oil adjuvant foot-and-mouth disease vaccine. 本发明公开了双相油佐剂口蹄疫疫苗的稳定剂及其应用。所述双相油佐剂口蹄疫疫苗的稳定剂，由酸、醇、胺、聚合物、糖、电荷调节剂和水组成，所述酸的用量为0.1～1％，所述醇的用量为0.1～2％，所述胺的用量为0.1～2％，所述电荷调节剂的用量为0.1～10％，所述聚合物用量为0.1～15％，所述糖用量为0.1～20％，余量为水。本发明的稳定剂提高了双相油佐剂口蹄疫疫苗的保存效果、免疫效力和安全水平。