Pyrrolotriazine derivative, and preparation method and application thereof

The invention provides a pyrrolotriazine derivative, and a preparation method and application thereof. The pyrrolotriazine derivative disclosed by the invention is a compound with a general formula I, can effectively inhibit the activity of AXL and c-Met kinase, can effectively inhibit the in-vivo growth of tumor cells, and has good safety and tolerance. The preparation method of the compound is simple in process and convenient for industrial production. 本发明提供吡咯并三嗪衍生物及其制备方法和应用。本发明的吡咯并三嗪衍生物为具有通式I的化合物，其能够有效地抑制AXL和c-Met激酶的活性，能够有效抑制肿瘤细胞的体内生长，并具有良好的安全性和耐受性。本发明化合物的制备方法工艺简单，便于工业化生产。