Substituted triazolo-pyridazing derivative, pharmaceutical composition made therefrom

Substituted triazolo-pyridazing derivative, pharmaceutical composition made therefrom

7-(1，1-二甲基乙基)-6-(2-乙基-2H-1，2，4-三唑-3-基甲氧基)-3-(2-氟苯基)-1，2，4-三唑并[4，3-b]哒嗪及其药学上可接受的盐为GABA#-[A]受体的选择性配体，特别是其具有对其α#-[2]和/或α#-[3]亚单位的高度亲合力，因而有效地用于治疗和/或预防中枢神经系统的异常，包括焦虑和惊厥。 7-(1,1 -Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine, and pharmaceuticall...

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Bibliographische Detailangaben
Hauptverfasser: C.J. COWDEN, J.L. CASTRO PINEIRO, W.R. CARLING
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:7-(1，1-二甲基乙基)-6-(2-乙基-2H-1，2，4-三唑-3-基甲氧基)-3-(2-氟苯基)-1，2，4-三唑并[4，3-b]哒嗪及其药学上可接受的盐为GABA#-[A]受体的选择性配体，特别是其具有对其α#-[2]和/或α#-[3]亚单位的高度亲合力，因而有效地用于治疗和/或预防中枢神经系统的异常，包括焦虑和惊厥。 7-(1,1 -Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine, and pharmaceutically acceptable salts thereof are selective ligands for GABAA receptors useful in the treatment of disorders of the central nervous system.