CD19 BINDING MOLECULES AND USES THEREOF

The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed. 本披露提供了特异性结合至CD19的CD19结合分子，包括单特异性、双特异性和三特异性结合分子；包含所述CD19结合分子的缀合物；以及包含所述CD19结合分子和缀合物的药物组合物。本披露进一步提供了使用所述C19结合分子治疗与CD19表达相关的疾病和障碍的方法。本披露还进一步提供了被工程化以表达所述CD19结合分子的重组宿主细胞，以及通过在表达所述CD19结合分子的条件下培养所述宿主细胞来产生所述CD19结合分子的方法。