DNA molecule for coding SARS-COV-2 virus C.37 mutant antigen, DNA vaccine and application

The invention relates to the technical field of biology and particularly provides a DNA molecule for coding an SARS-COV-2 virus C.37 mutant antigen, a DNA vaccine and application of the DNA molecule and the DNA vaccine. A nucleic acid sequence SEQ ID NO: 1 provided by the invention can be efficientl...

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Bibliographische Detailangaben
Hauptverfasser:	ZHAO GAN, DING YUAN, HOU JIAWANG, YU QINGLING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the technical field of biology and particularly provides a DNA molecule for coding an SARS-COV-2 virus C.37 mutant antigen, a DNA vaccine and application of the DNA molecule and the DNA vaccine. A nucleic acid sequence SEQ ID NO: 1 provided by the invention can be efficiently transcribed and expressed in a eukaryotic expression system, has immunogenicity and is expressed in humoral immunity and cellular immunologic response, and a nucleic acid vaccine taking the nucleic acid sequence SEQ ID NO: 1 as an active component also has good immunogenicity. 本发明涉及生物技术领域，具体而言，提供了一种编码SARS-COV-2病毒C.37突变株抗原的DNA分子、DNA疫苗及应用。本发明提供的SEQ ID NO：1核酸序列在真核表达系统中能够高效转录和表达，而且具有免疫原性，表现在体液免疫和细胞免疫应答中，以此作为活性成分的核酸疫苗同样具有良好的免疫原性。