Dehalogenation method of 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the step of reacting a compound I with sulfo fatty acid salt to obta...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: REN NAN, HAN KUNYING
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the step of reacting a compound I with sulfo fatty acid salt to obtain a 9-bit dehalogenation product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, the compound I and the sulfo fatty acid salt react to obtain the 9-bit dehalogenation product compound II of the 9-halogenated steroid compound, reagents such as zinc powder, chromium particles or tri-n-butyltin which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the dehalogenation method is green and environmentally friendly, the synthesis process is simple and easy to implement, and the production applicability is improved. 本发明提供了一种9-卤代甾体化合物的脱卤方法及应用,涉及化学合成技术领域。9-卤代甾体化合物的脱卤方法,包括如下步骤:化合物I与硫代脂肪酸盐反应,得到9-卤代