Method for synthesizing deoxytazobactam diphenylmethyl ester by adopting novel catalyst
The invention discloses a method for synthesizing deoxytazobactam diphenylmethyl ester by adopting a novel catalyst. The method comprises the following steps: firstly, preparing a bimetallic coordination polymer by adopting a solvothermal method, then loading the prepared bimetallic coordination pol...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for synthesizing deoxytazobactam diphenylmethyl ester by adopting a novel catalyst. The method comprises the following steps: firstly, preparing a bimetallic coordination polymer by adopting a solvothermal method, then loading the prepared bimetallic coordination polymer in a pore channel of silica gel by taking the silica gel as a carrier, and better stabilizing the prepared bimetallic coordination polymer in the pore channel through metal reduction, so that reduction of active sites caused by reaction is prevented, and the stability and recoverability of the catalyst are improved; therefore, the weakly alkaline supported bimetallic porous coordination polymer catalyst which can be repeatedly used and is relatively high in activity and good in stability is obtained. When the catalyst is used for synthesizing desoxidized tazobactam diphenylmethyl ester, a two-phase system of acetone and water is adopted in the reaction, so that the triazole reaction time is greatly shortened, |
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