Synthesis method of 2-(2-methoxyphenoxy)ethylamine

The invention provides a synthesis method of 2-(2-methoxyphenoxy)ethylamine, and belongs to the technical field of organic synthesis. According to the invention, guaiacol, urea and ethanolamine are taken as starting raw materials, and the 2-(2-methoxyphenoxy)ethylamine is synthesized by completing a three-step reaction through a 'one-pot method'. The invention provides a brand new synthesis thought of 2-(2-methoxyphenoxy)ethylamine, innovatively avoids direct use of expensive 2-oxazolidinone, uses urea and ethanolamine to synthesize 2-oxazolidinone, and then directly reacts with guaiacol under the catalysis of alkali to generate 2-(2-methoxyphenoxy)ethylamine. 本发明提供了一种2-(2-甲氧基苯氧基)乙胺的合成方法，属于有机合成技术领域。本发明以愈创木酚、尿素和乙醇胺为起始原料，通过"一锅法"完成三步反应合成2-(2-甲氧基苯氧基)乙胺。提供了一种全新的2-(2-甲氧基苯氧基)乙胺合成思路，创新地避免直接使用价格昂贵的2-恶唑烷酮，利用尿素和乙醇胺合成2-恶唑烷酮，再以碱的催化下直接与愈创木酚反应生成2-(2-甲氧基苯氧基)乙胺。