CELL FUSION-INDUCING VACCINIA VIRUS AND USE THEREOF

The purpose of the present invention is to provide: a vaccinia virus that induces cell fusion of infected cells; and a method for producing the same. The present invention is a vaccinia virus which lacks the function of the K2L gene or the HA gene, or both the functions of the K2L gene and the Ha ge...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	NAKAMURA TAKAFUMI, KUWANO NOZOMI, NAKATAKE MOTOMU, KUROSAKI HAJIME
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The purpose of the present invention is to provide: a vaccinia virus that induces cell fusion of infected cells; and a method for producing the same. The present invention is a vaccinia virus which lacks the function of the K2L gene or the HA gene, or both the functions of the K2L gene and the Ha gene and is mutated to cause specific cell fusion of infected cells, in which cell fusion of the infected cells occurs to thereby induce cell death. 本发明的目的在于提供一种诱导受感染细胞的细胞融合的痘苗病毒及其制备方法。本发明是一种突变的痘苗病毒，其能够引起受感染细胞的特异性细胞融合，其中，K2L基因或HA基因、或者K2L基因和HA基因的功能发生了缺陷，所述痘苗病毒引起受感染细胞的细胞融合，诱导细胞死亡。