Alkyne phenyl benzamide compound and application thereof

The invention relates to an alkyne phenyl benzamide compound and application thereof. The alkyne phenyl benzamide compound has a structure as shown in a formula (I), can be used as a protein kinase inhibitor, can effectively inhibit the activity of TRK protein kinase and inhibit proliferation, migra...

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Bibliographische Detailangaben
Hauptverfasser:	DING KE, WANG JIE, WANG ZUQIN, TANG XIA, XIANG SHUANG, TU ZHENGCHAO, ZHANG ZHANG, LU XIAOYUN, ZHANG ZHIMIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to an alkyne phenyl benzamide compound and application thereof. The alkyne phenyl benzamide compound has a structure as shown in a formula (I), can be used as a protein kinase inhibitor, can effectively inhibit the activity of TRK protein kinase and inhibit proliferation, migration and invasion of various tumor cells, and has the characteristics of good pharmacokinetics and low toxicity. 本发明涉及一种炔苯基苯酰胺类化合物及其应用。本发明的炔苯基苯酰胺类化合物具有式(I)所示结构，该类化合物可作为蛋白激酶抑制剂，能够有效抑制TRK蛋白激酶的活性并且能抑制多种肿瘤细胞的增殖、迁移和侵袭，同时具有较好的药代动力学和毒性低的特点。