Synthesis method of bis (4-methyl-2-amyl) phthalate or stable isotope labeled compound thereof

The invention discloses a synthesis method of bis (4-methyl-2-amyl) phthalate or a stable isotope labeled compound thereof. According to the synthesis method, by using a Steglich esterification reaction for the first time, phthalic acid or stable isotope labeled phthalic acid is taken as a raw material and reacts with 4-methyl-2-amyl alcohol under the combined action of a catalyst and a coupling reagent to synthesize bis (4-methyl-2-amyl) phthalate or a stable isotope labeled compound thereof. According to the invention, the synthesis method is simple and convenient to operate and low in energy consumption, the stable isotope is not obviously diluted, the product is easy to separate and purify and high in yield, the chemical purity and the abundance of the stable isotope both reach 98.0% or above, and the product can be used as an internal standard reagent for detecting the phthalate plasticizers and has good economical efficiency. 本发明公开了一种邻苯二甲酸二(4-甲基-2-戊基)酯或其稳定同位素标记物的合成方法。该合成方法首次利用Steglich酯化反应，以邻苯二甲酸或稳定同位素标记