Application of chitosan oligosaccharide in improving intestinal permeability and serving as oral absorption enhancer of BCSIII drugs

The invention relates to application of chitosan oligosaccharide in improving intestinal permeability and serving as an oral absorption enhancer of BCSIII drugs, and belongs to the technical field of chitosan oligosaccharide application. The application of the chitosan oligosaccharide in improving the intestinal permeability is based on the principle that the chitosan oligosaccharide can open tight connection between intestinal microvilli epithelial cells to improve the intestinal permeability, and the application of promoting in-vivo absorption of low-permeability drugs is developed. In addition, the invention further discloses the application of the chitosan oligosaccharide serving as the oral absorption enhancer of the BCSIII drugs. The main component in the BCSIII drugs is triflumurin, the chitosan oligosaccharide is taken first to open the tight connection between the intestinal microvilli epithelial cells, then the BCSIII drugs are taken, after the chitosan oligosaccharide and the intestinal mucosa act