Conotoxin-entrapped chitosan nanoparticle emulsion and preparation method thereof

The invention discloses a conotoxin-entrapped chitosan nanoparticle emulsion and a preparation method thereof, and belongs to the technical field of high polymer materials. The emulsion is prepared from the following raw materials in parts by weight: 1 part of conotoxin, 2 to 4 parts of chitosan, 0.1 to 0.5 part of sodium tripolyphosphate, 100 to 400 parts of greasy components, 40 to 160 parts of emulsifier, 80 to 200 parts of auxiliary emulsifier, 80 to 160 parts of humectant and 10 to 30 parts of thickening agent. According to the invention, the conotoxin is coated with the chitosan to prepare nano-particles, and the nano-particles are prepared into an emulsion, which promotes the conotoxin to continuously permeate into the deep layer of skin to play a role in removing wrinkles; meanwhile, the ingredients such as the auxiliary emulsifier and the humectant are added, which helps hydration of skin cuticle, so that transdermal permeation of the conotoxin nanoparticles is enhanced; all the raw materials act tog