Downscaling parameters to design experiments and plate models for micro-organisms at small scale to improve prediction of performance at larger scale

Systems, methods and computer-readable media are provided for designing experiments for organisms at a first scale to generate first-scale performance data used in predicting performance of the organisms at a second, larger scale. The design includes determining first-scale screening conditions based at least in part on the contribution of second-scale conditions to performance parameters of an organism at the second scale. The first-scale screening conditions include one or more proxies for second-scale conditions that cannot be replicated at first scale. The design determines first-scale screening parameters based at least in part on computer modeling of the metabolism of the organism at the second scale. 提供用于设计在第一规模下的生物体的实验以产生用于预测在第二更大规模下的所述生物体的性能的第一规模性能数据的系统、方法及计算机可读媒体。所述设计包含至少部分地基于第二规模条件对在所述第二规模下的生物体的性能参数的贡献来确定第一规模筛选条件。所述第一规模筛选条件包含无法在第一规模下复制的第二规模条件的一或多个代理。所述设计至少部分地基于在所述第二规模下的所述生物体的代谢的计算机建模来确定第一规模筛选参数。