Method for detecting p-hydroxyacetophenone related substances

The invention relates to the technical field of drug analysis and detection, and particularly discloses a method for detecting p-hydroxyacetophenone related substances. According to the method, related substances are determined by adopting a gas chromatographic method, and chromatographic conditions...

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Hauptverfasser: HAN QIANRU, ZHAO JINGYE, ZHANG GUANHUA, LUO HUIRU, YIN YUXIN, LIU PENG, WANG YAJING, MA MINGZHUO, BI HE, RONG ZIHANG, SUN LIJIE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of drug analysis and detection, and particularly discloses a method for detecting p-hydroxyacetophenone related substances. According to the method, related substances are determined by adopting a gas chromatographic method, and chromatographic conditions are as follows: a chromatographic column is a capillary column taking phenyl-dimethyl polysiloxane as a stationary liquid; the flow velocity of the carrier gas is 0.5-1.5 ml/min; the split ratio is (8-12): 1; in the heating procedure, the initial temperature is 45-55 DEG C, the temperature is increased to 215-225 DEG C at the speed of 8-12 DEG C per minute, and the temperature is maintained for 5-10 minutes; the temperature of a sample inlet is 240-260 DEG C; a detector is a hydrogen flame ionization detector, and the temperature of the detector is 240-260 DEG C. According to the detection method provided by the invention, effective separation of p-hydroxyacetophenone from 2'-hydroxyacetophenone, 3'-hydroxyacetoph