Antibody specifically combined with human CTLA4 and medicine and kit containing antibody

The invention discloses an antibody specifically combined with human CTLA4. The antibody comprises three complementarity determining regions; and the three complementarity determining regions are correspondingly a CDR1 with an amino acid sequence as shown in SEQ ID NO: 1, a CDR2 with an amino acid sequence as shown in SEQ ID NO: 2 and a CDR3 with an amino acid sequence as shown in SEQ ID NO: 3. The invention further discloses a medicine and a kit containing the antibody. The antibody has the following characteristics but is not limited to the following properties that (1), the antibody has high affinity and specificity with human CTLA4; (2), the interaction between CTLA4 and CD86 or CD80 can be blocked; (3), CTLA4 overexpression cells can be specifically combined; (4), the activation of PBMC and/or T cells is enhanced; and (5), tumor growth is inhibited. 本发明公开了一种特异性结合人CTLA4的抗体，其包括3个互补性决定区；3个所述的互补性决定区分别为：氨基酸序列如SEQ ID NO:1所示的CDR1，氨基酸序列如SEQ ID NO:2所示的CDR2，以及氨基酸序列如SEQ ID NO:3所示的CDR3。本发明还公开了包含上述抗体的药物与试剂盒。本发明的抗体展现出