可以自组装形成PH响应载药水凝胶的多肽、水凝胶及其制备方法和用途

本发明公开了可以自组装形成PH响应载药水凝胶的多肽、水凝胶及其制备方法和用途，多肽序列为：FOVVVEF，其中，F＝苯丙氨酸，O＝鸟氨酸，V＝缬氨酸，E＝谷氨酸。通过固相合成法合成具有七个氨基酸的多肽，该多肽自组装形成包裹盐酸阿霉素的多肽水凝胶。本发明的多肽具有良好的生物相容性和生物可降解性，机械性能好，在包裹药物后可以达到缓释效果，对PH具有较高的敏感性，通过肿瘤部位原位注射方式将载药凝胶注射到肿瘤周围，该载药多肽水凝胶在酸性肿瘤微环境的刺激下，可以实现抗肿瘤药物的靶向缓释给药，提高化疗效果，提高抗肿瘤效果，降低毒副作用。 The invention discloses polypeptide capable of forming PH response drug-loaded hydrogel through self-assembly, hydrogel and a preparation method and application thereof. The polypeptide sequence is FOVVVEF, F is phenylalanine, O is ornithine, V is valine, and E is glutamic acid. Polypeptide with seven amino acids is synthesized through a solid-phase synthesis method, and the polypeptide is self-assembled to form the polypeptide hydrogel wrapping doxorubicin hydrochloride. The polypeptide has good biocompatibility, biodegradability and mechanical performance, can achieve a slow release effect after wrapping a drug, has high sensitivity to PH, and injects the drug-loaded gel to the periphery of a tumor in a tumor site in-situ injection mode; and unde