TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION

Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs. 除其他事项外，本披露提供了用于寡核苷酸制备、特别是手...

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Hauptverfasser:	BOMMINENI GOPAL REDDY, KANDASAMY PACHAMUTHU, BOWMAN KEITH ANDREW, SHIMIZU MAMORU, KUMARASAMY JAYAKANTHAN, STANDLEY STEPHANY MICHELLE, ALAM MOHAMMED ROWSHON, BHATTARAI BIJAY TILAK, BUTLER DAVID CHARLES DONNELL, VARGEESE CHANDRA, DIVAKARAMENON SETHUMADHAVAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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Beschreibung
Zusammenfassung:	Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs. 除其他事项外，本披露提供了用于寡核苷酸制备、特别是手性控制的寡核苷酸制备的技术，所述技术提供了大大改善的粗品纯度和产率，并显著降低了制造成本。