Hydrogenation protecting group removal method for improving palladium carbon activity

The invention discloses a hydrogenation protection group removal method for improving palladium carbon activity, which comprises the following steps of: adding an alcohol organic solvent, a catalyst Pd/C and a salt for improving palladium carbon activity into a compound which is used as a raw materi...

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Hauptverfasser: JIANG YUTONG, YANG ZHUHONG, LU YASONG, YANG FULIU, FAN JIXUE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a hydrogenation protection group removal method for improving palladium carbon activity, which comprises the following steps of: adding an alcohol organic solvent, a catalyst Pd/C and a salt for improving palladium carbon activity into a compound which is used as a raw material and is required to be subjected to protection group removal, carrying out hydrogenation at room temperature to 60 DEG C in a normal-pressure hydrogen environment, after the reaction is finished, filtering, carrying out reduced pressure distillation, and dissolving in an extraction solvent, and after extraction and reduced pressure distillation, obtaining a hydrogenated product. By adding the salt for improving the activity of palladium carbon, the activity of the palladium carbon is improved, the reaction rate is increased, the requirements of the reaction on equipment are reduced, the reaction danger and cost are reduced, and good economic benefits are achieved. 本发明公开了一种提高钯碳活性加氢脱除保护基的方法,以需要脱除保护基的化合物为原料,加入醇类有机溶剂