Novel preparation method of isoquinoline compound

The invention discloses a novel preparation method of an isoquinoline compound, which comprises the following steps of: carrying out ring opening alkylation on phthalic anhydride as an initial raw material to obtain an intermediate Int1, carrying out reduction cyclization on the Int1 to obtain Int2, carrying out bromination on the Int2 to obtain Int3, carrying out ring opening esterification on the Int3 to obtain Int4, carrying out cyclization on the Int4 to obtain Int5, and coupling the Int5 with phenol to obtain an isoquinoline compound B. The method has the advantages of cheap and easily available raw materials, simple reaction route, high operation safety, convenient post-treatment, convenient purification of each intermediate, and high overall yield, and is suitable for large-scale production. 本发明公开了一种异喹啉化合物的制备新方法，以邻苯二甲酸酐为起始原料，经开环烷基化制得中间体Int1,Int1经还原环合得到Int2，Int2经溴代得到Int3，Int3经开环酯化得到Int4，Int4经环合得到Int5，Int5与苯酚偶联得到异喹啉化合物B。本发明原料价格低廉易得，反应路线简单，操作安全度高，后处理方便，各中间体纯化方便，整体收率较高，适合规模化生产。