Bongkrekic acid high-selectivity enrichment solid-phase micro-extraction probe as well as preparation method and application thereof

The invention discloses a preparation method of a bongkrekic acid high-selectivity enrichment solid-phase micro-extraction probe. The preparation method comprises the following steps of: providing a solid substrate; carrying out surface modification on the solid substrate to enable the surface of the solid substrate to be rich in methacryloyloxy so as to obtain a surface modified solid substrate; and carrying out a molecular imprinting polymerization reaction on the surface modified solid substrate through a molecular imprinting technology by taking methacryloyloxyethyl trimethyl ammonium chloride and octadecyl methacrylate as functional monomers and vitamin A acid and (R)-12-hydroxy-cis-9-octadecenoic acid as template molecules to enable a molecularly imprinted coating with high selective adsorption capacity on bongkrekic acid to be attached to the surface of the solid substrate. The solid-phase micro-extraction probe disclosed by the invention can be used for efficiently extracting and enriching bongkrekic