Tetrandrine derivative lipid nanosuspension and preparation method thereof

The invention provides a tetrandrine derivative lipid nanosuspension and a preparation method thereof. The tetrandrine derivative lipid nanosuspension comprises or consists of a tetrandrine derivative, phospholipid and poloxamer, wherein the tetrandrine derivative is 7-O-(O-bromobenzenesulfonyl) tetrandrine and/or pharmaceutically acceptable salt thereof. The tetrandrine derivative lipid nanosuspension provided by the invention has good stability, high encapsulation efficiency and drug loading capacity, can exert excellent cytotoxicity, and has obvious cytotoxicity to lung cancer cells due to the same mass of original medicinal water solvent and clinically common drug hydroxycamptothecine. 本申请提供一种防己诺林碱衍生物脂质纳米混悬剂及其制备方法，所述防己诺林碱衍生物脂质纳米混悬剂包含或由防己诺林碱衍生物、磷脂和泊洛沙姆组成；其中，所述防己诺林碱衍生物为7-O-(o-溴苯磺酰基)防己诺林碱和/或其药学上可接受的盐。本发明提供了防己诺林碱衍生物脂质纳米混悬剂，其具有良好的稳定性，较高的包封率和载药量。并能发挥出优异的细胞毒性，其针对肺癌细胞的细胞毒性显著由于其等质量的原药水溶剂以及临床上的常用药羟基喜树碱。