METHOD FOR PRODUCING PEPTIDE COMPOUND

The present invention addresses the problem of providing a method for highly efficiently producing a peptide. This method for producing a peptide comprises the following step (1): (1) A step in which a silylated amino acid or peptide, obtained by reacting a silylating agent with an amino acid or peptide represented in formula (III), is reacted in a flow reactor with a peptide with an activated C-terminal carboxyl group, obtained by reacting an acid halide and a tertiary amine represented by formula (II) with an N-protected peptide represented by formula (I) in a flow reactor [in formulas [I] to [III], AA1, AA2, P, R1, R2 and R3 are as described in the description and the claims.] Formula (I): P-AA1-OH (I) Formula (II): Formula (III): H-AA2-OH (III). 本发明的课题在于提供肽的高效率的制造方法。肽的制造方法，其包括下述工序(1)：工序(1)，使C末端羧基被活化的肽与经甲硅烷基化的氨基酸或肽在流动反应器中反应，其中，所述C末端羧基被活化的肽是使酰卤化物及式(II)表示的叔胺与式(I)表示的N-保护肽在流动反应器中反应而得到的，所述经甲硅烷基化的氨基酸或肽是使式(III)表示的氨基酸或肽与甲硅烷基化剂反应而得到的[式(I)～(III)中，AA1、AA2、P、R1、R2及R3如本说明书及权利要求书的记载]。式(I)：P-AA1-OH (I)式(II)：式(III)：H-AA2-