MELOXICAM CO-CRYSTAL COMPOSITIONS

The solubility and bioavailability properties of meloxicam can be improved by preparing compositions of meloxicam co-crystals and reducing the particle size of (e.g., "nanosizing") co-crystals. Such compositions with improved dissolution pharmacokinetic properties can be prepared by granulation and blending the co-crystals with extragranular excipients to provide oral solid dosage forms. As a result of the improved properties of the meloxicam oral dosage forms, the compositions may be useful for the treatment of pain, including acute pain. 美洛昔康的溶解性和生物等效性可以通过制备美洛昔康共晶的组合物并减小(例如"纳米化")共晶的粒度来改善。所述具有改进的溶解度药代动力学性质的药物组合物可以通过将共晶和颗粒外赋形剂进行造粒和混合以制成口服固体剂型。由于美洛昔康口服剂型的改善的性质，该组合物可用于治疗疼痛，包括急性疼痛。