MiRNA related to sheep F17 escherichia coli and application thereof

The invention provides a molecular marker miR-299-5p related to sheep F17 escherichia coli, a targeted sheep beta defensin 2 gene (SBD2) of the miR-299-5p and application of miRNA in researching F17 escherichia coli infection resistance of sheep small intestine epithelial cells. The NCBI sequence nu...

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Bibliographische Detailangaben
Hauptverfasser:	ZOU SHUANGXIA, GE LING, SUN WEI, YUAN ZEHU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a molecular marker miR-299-5p related to sheep F17 escherichia coli, a targeted sheep beta defensin 2 gene (SBD2) of the miR-299-5p and application of miRNA in researching F17 escherichia coli infection resistance of sheep small intestine epithelial cells. The NCBI sequence number of the SBD2 gene is NM_001198545.1 and the miR-299-5p can be used for improving the capability of the small intestine epithelial cells of resisting the F17 escherichia coli infection. According to the molecular marker miR-299-5p provided by the invention, the F17 escherichia coli infection resistance of the small intestine epithelial cells can be regulated and controlled through negative regulation and control of a target gene, and the effect of the SBD2 in the F17 escherichia coli infection resistance of the small intestine epithelial cells of Huyang sheep and researches of a regulation and control mechanism of the SBD2 can be deeply explored, so that certain theoretical evidences are provided for application