Chiral amide compound and synthesis method thereof
The invention relates to a chiral amide compound and a synthesis method thereof. The structural general formula of the chiral amide compound is shown in the specification, chiral carboxylic acid is used as a basic raw material, carboxyl is converted into acyl chloride, the acyl chloride is condensed...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a chiral amide compound and a synthesis method thereof. The structural general formula of the chiral amide compound is shown in the specification, chiral carboxylic acid is used as a basic raw material, carboxyl is converted into acyl chloride, the acyl chloride is condensed with aliphatic amine or alkoxy amido, the chiral amide is synthesized at high yield, the reaction operation is simple and convenient, and the efficiency is high. The chiral amino acid is used as a raw material, the amide compound is synthesized through a simple three-step method, the yield is high, the chirality of the obtained compound is determined by the chirality of the raw material amino acid, and the substrate selection range is wide; and the obtained amide compound can be used as a ligand, and has a plurality of modifiable sites, so that the electrical property of the ligand can be changed, and the steric hindrance of the ligand can be increased, and therefore, the amide compound can adapt to different cata |
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