Silk fibroin microneedle transdermal patch for treating insomnia and preparation method of silk fibroin microneedle transdermal patch

The invention discloses a silk fibroin microneedle transdermal patch for treating insomnia and a preparation method of the silk fibroin microneedle transdermal patch. The preparation method comprises the following steps: respectively preparing aqueous solutions of a microneedle matrix modification additive, a drug dissolution additive and a drug release additive; adding melatonin into the aqueous solution of the drug dissolution additive to obtain a melatonin solution; adding the aqueous solution of the microneedle matrix modification additive and the melatonin solution into a silk fibroin aqueous solution, and then adding the aqueous solution of the drug release additive to obtain a mixed solution II; pouring the mixed solution II into a microneedle mold, and performing vacuum defoaming, drying and demolding to obtain the silk fibroin microneedle transdermal patch for treating insomnia. The melatonin microneedle patch prepared by the invention can quickly reach a certain blood level and maintain a high conce