New crystal form of empagliflozin intermediate and preparation method thereof

The invention provides a novel crystal form of an empagliflozin intermediate, and more particularly provides a novel crystal form of (3S)-3-[4-[(5-bromo-2-chlorphenyl) methyl] phenoxy] tetrahydrofuran and a preparation method thereof, and the novel crystal form is higher in melting point and lower in hygroscopicity. The novel crystal form grows in a pressure range suitable for industrial production conditions to form a crystal nucleus, and is prepared through cooling and water-promoted crystallization, the preparation method is simple in reaction and high in operability, and the prepared product is good in quality and high in yield and is a preparation process suitable for industrialization. 本发明提供了一种恩格列净中间体的新晶型，更具体而言，本发明提供了(3S)-3-[4-[(5-溴-2-氯苯基)甲基]苯氧基]四氢呋喃的新晶型及其制备方法，该新晶型熔点更高、引湿性更低。该新晶型在适合工业生产条件下的压力范围内养晶形成晶核，并通过降温和水促析晶制得，制备方法反应简单、可操作性高、制备的产品质量好、收率高，是适合产业化的制备工艺。