Continuous flow teriflunomide preparation process

The invention discloses a continuous flow teriflunomide preparation process which comprises the following steps: using a continuous flow reactor, taking cyanoacetic acid as a starting material, preparing cyanoacetyl chloride through chlorination, synthesizing a teriflunomide intermediate through the cyanoacetyl chloride and p-trifluoromethylaniline, and synthesizing teriflunomide through the intermediate and acetyl chloride. The method has the advantages of high safety, low cost, low energy consumption and high production yield. 本发明公开了一种连续流特立氟胺制备工艺，使用连续流反应器，以氰基乙酸为起始物料，通过氯代制备氰基乙酰氯，通过氰基乙酰氯与对三氟甲基苯胺合成特立氟胺中间体，中间体与乙酰氯合成特立氟胺。本发明具有安全性高、成本低、耗能低、生产收率高的优点。