Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone
The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone. A compound A is used as a basic raw material, and 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is obtained through Blanc chlorom...
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| creator | JIN LUYI CHEN JIANLONG |
| description | The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone. A compound A is used as a basic raw material, and 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is obtained through Blanc chloromethylation, substitution reaction, Claisen ester condensation and hydrolysis reaction in sequence. The synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is high in purity, high in yield and simple to operate.
本发明属于化学中间体技术领域，具体涉及一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。本发明以化合物A作为基础原料，依次通过Blanc氯甲基化，取代反应，克莱森酯缩合，水解反应，从而得到1-苯基-3-(3-三氟甲基苯基)-2-丙酮，本发明为1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成，提供了一种纯度高、收率高且操作简单的1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。 |
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本发明属于化学中间体技术领域，具体涉及一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。本发明以化合物A作为基础原料，依次通过Blanc氯甲基化，取代反应，克莱森酯缩合，水解反应，从而得到1-苯基-3-(3-三氟甲基苯基)-2-丙酮，本发明为1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成，提供了一种纯度高、收率高且操作简单的1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211119&DB=EPODOC&CC=CN&NR=113666817A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211119&DB=EPODOC&CC=CN&NR=113666817A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIN LUYI</creatorcontrib><creatorcontrib>CHEN JIANLONG</creatorcontrib><title>Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone</title><description>The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone. A compound A is used as a basic raw material, and 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is obtained through Blanc chloromethylation, substitution reaction, Claisen ester condensation and hydrolysis reaction in sequence. The synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is high in purity, high in yield and simple to operate.
本发明属于化学中间体技术领域，具体涉及一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。本发明以化合物A作为基础原料，依次通过Blanc氯甲基化，取代反应，克莱森酯缩合，水解反应，从而得到1-苯基-3-(3-三氟甲基苯基)-2-丙酮，本发明为1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成，提供了一种纯度高、收率高且操作简单的1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAKrswryUgtzixWyE0tychPUchPUzDULchIzavM0TXW1TDWLSnKTMspzS_KBymozIFIaeoa6SYmp5bk56XyMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4gKgsrzUknhnP0NDYzMzMwtDc0djYtQAAOSXMVc</recordid><startdate>20211119</startdate><enddate>20211119</enddate><creator>JIN LUYI</creator><creator>CHEN JIANLONG</creator><scope>EVB</scope></search><sort><creationdate>20211119</creationdate><title>Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone</title><author>JIN LUYI ; CHEN JIANLONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113666817A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>JIN LUYI</creatorcontrib><creatorcontrib>CHEN JIANLONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIN LUYI</au><au>CHEN JIANLONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone</title><date>2021-11-19</date><risdate>2021</risdate><abstract>The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone. A compound A is used as a basic raw material, and 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is obtained through Blanc chloromethylation, substitution reaction, Claisen ester condensation and hydrolysis reaction in sequence. The synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is high in purity, high in yield and simple to operate.
本发明属于化学中间体技术领域，具体涉及一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。本发明以化合物A作为基础原料，依次通过Blanc氯甲基化，取代反应，克莱森酯缩合，水解反应，从而得到1-苯基-3-(3-三氟甲基苯基)-2-丙酮，本发明为1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成，提供了一种纯度高、收率高且操作简单的1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone |
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