Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone
The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone. A compound A is used as a basic raw material, and 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is obtained through Blanc chlorom...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone. A compound A is used as a basic raw material, and 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is obtained through Blanc chloromethylation, substitution reaction, Claisen ester condensation and hydrolysis reaction in sequence. The synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone is high in purity, high in yield and simple to operate.
本发明属于化学中间体技术领域，具体涉及一种1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。本发明以化合物A作为基础原料，依次通过Blanc氯甲基化，取代反应，克莱森酯缩合，水解反应，从而得到1-苯基-3-(3-三氟甲基苯基)-2-丙酮，本发明为1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成，提供了一种纯度高、收率高且操作简单的1-苯基-3-(3-三氟甲基苯基)-2-丙酮的合成方法。 |
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