Application of sertraline and benzalkonium chloride in preparation of preparation for inhibiting and/or killing pathogenic bacteria

The invention provides application of sertraline and benzalkonium chloride in preparation of a preparation for inhibiting and/or killing pathogenic bacteria, and belongs to the technical field of public health and breeding environment application. The sertraline can inhibit the expression of virulence genes of the staphylococcus aureus and the listeria monocytogenes, and the sertraline and the benzalkonium chloride are combined for use, so that the dosage of the benzalkonium chloride can be reduced, and the drug resistance of the staphylococcus aureus and the listeria monocytogenes to the benzalkonium chloride can be reduced; the environmental pollution caused by staphylococcus aureus and listeria monocytogenes can be effectively prevented. Through verification, the additive amount of sertraline is 4-32 [mu] g/ml, and the MIC value of benzalkonium chloride is reduced by about 1/2. 本发明提供了舍曲林和苯扎氯铵在制备抑制和/或杀灭致病菌的制剂中的应用，属于公共卫生及养殖环境应用技术领域。舍曲林能够能够抑制金黄色葡萄球菌和单核细胞增生李斯特菌毒力基因的表达，舍曲林与苯扎氯铵联用能够减少苯扎氯铵的用量，降低金黄色葡萄球菌和单核细胞增生李斯特菌