Hydrogel composition, hydrogel as well as preparation method and application of hydrogel

The invention discloses a hydrogel composition, hydrogel as well as a preparation method and application of the hydrogel. The hydrogel composition is prepared from the following components in parts by weight: 1 to 9 parts of quaternized chitosan QCS, 5 to 25 parts of methylacryloyl gelatin GelMA, 28 to 112 parts of sulfobetaine SBMA, 0.02 to 2 parts of initiator and 100 parts of water. The prepared hydrogel has good biocompatibility, excellent mechanical properties, water-retaining property, freezing resistance and bacterial adhesion resistance, the tensile strength can reach 4.73 MPa to the maximum, and the compression strength can reach 10.82 MPa to the maximum. The application field of the hydrogel is widened. 本发明公开了一种水凝胶组合物、水凝胶及其制备方法和应用，所述水凝胶组合物包括1-9重量份季铵化壳聚糖QCS、5-25重量份甲基丙烯酰明胶GelMA、28-112重量份磺酸甜菜碱SBMA、0.02-2重量份引发剂、100重量份水。具有良好的生物相容性、优异的机械性能、保水性、抗冻性及抗细菌黏附性能，拉伸强度最高可达4.73MPa，压缩强度最高可达10.82MPa。拓宽了水凝胶的应用领域。