Pyrrolidine compound and application thereof

The invention discloses a pyrrolidine compound as shown in a formula I or a pharmaceutically acceptable salt, an enantiomer, a diastereoisomer or a raceme of the pyrrolidine compound, wherein the definition of each group in the formula is shown in the specification. In addition, the invention also d...

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Bibliographische Detailangaben
Hauptverfasser:	LI YUE, HE JING, ZHANG QI, GE RUI, PAN SHUNJIE, CHEN WENHUA, KUAI LETIAN, SU WENJI, WU ALIANG, AN YULONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses a pyrrolidine compound as shown in a formula I or a pharmaceutically acceptable salt, an enantiomer, a diastereoisomer or a raceme of the pyrrolidine compound, wherein the definition of each group in the formula is shown in the specification. In addition, the invention also discloses a pharmaceutical composition containing the compound, and application of the pharmaceutical composition in preparation of drugs for inhibiting 3CL hydrolase (Mpro) of coronavirus. 本发明公开了一种如式I所示的吡咯烷类化合物或其药学上可接受的盐、对映异构体、非对映异构体或外消旋体，式中各基团的定义详见说明书。此外，本发明还公开了包括该化合物的药物组合物，及其在制备抑制冠状病毒的3CL水解酶(Mpro)的药物中的用途。