Method for preparing 1,5-benzo thia azatropy olerivative

Method for preparing 1,5-benzo thia azatropy olerivative

本发明涉及由式(I)化合物制备式(IV)表示的3-乙酰氧基5-(β-二甲基氨乙基)-1，5-苯并硫氮杂衍生物或其药学上可接受盐的方法，其中R是低级烷基，所述的方法包括将化合物(I)用已知的方法转化成相应的3-乙酰氧基-(β-二甲基氨乙基)-1，5-苯并硫氮杂衍生物或其药学上可接受的盐。∴ There is disclosed a process for preparing 1,5-benzothiazepine derivatives represented by the formula: wherein R is a lower alkyl group, which comprises su...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OKUNO YASU, HAYASHI HIROTOKU, NISHIMOTO SHIGERY
Format: Patent
Sprache:chi ; eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:本发明涉及由式(I)化合物制备式(IV)表示的3-乙酰氧基5-(β-二甲基氨乙基)-1，5-苯并硫氮杂衍生物或其药学上可接受盐的方法，其中R是低级烷基，所述的方法包括将化合物(I)用已知的方法转化成相应的3-乙酰氧基-(β-二甲基氨乙基)-1，5-苯并硫氮杂衍生物或其药学上可接受的盐。∴ There is disclosed a process for preparing 1,5-benzothiazepine derivatives represented by the formula: wherein R is a lower alkyl group, which comprises subjecting a propionic acid compound represented by the formula: wherein R has the same meaning as defined above, to intramolecular ring closing reaction in the presence of a sulfonic acid compound represented by the formula: R SO3H (III) wherein R represents a lower alkyl group or a substituted or unsubstituted phenyl group.