METHOD FOR PRODUCING PEPTIDE COMPOUND
The present invention provides a method for producing a peptide containing an N-alkyl amino acid, the method comprising the following steps (1) to (3). Step (1): Mix an N-terminus protected amino acid or an N-terminus protected peptide with a carboxylic acid halide or a halogenated alkyl formate; st...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ASAKA YUKIO KOBAYASHI YUTAKA TAKEUCHI HISAYUKI NAGAYA AKIHIRO TAGURI TOMONORI KURASAKI HARUAKI CARY DOUGLAS ROBERT MASUYA KEIICHI NEMOTO YOSHITAKA MATSUDA AYUMU HANDA MICHIHARU |
| description | The present invention provides a method for producing a peptide containing an N-alkyl amino acid, the method comprising the following steps (1) to (3). Step (1): Mix an N-terminus protected amino acid or an N-terminus protected peptide with a carboxylic acid halide or a halogenated alkyl formate; step (2): mix an amino acid or peptide, in which the N-terminus and C-terminus are not protected, with a trialkyl silylating agent; and step (3): mix the product obtained in step (1) with the product obtained in step (2).
本发明提供含有N-烷基氨基酸的肽的制造方法,其包括下述工序(1)至(3)。工序(1)：将N末端保护氨基酸或N末端保护肽与羧酸卤化物或卤代甲酸烷基酯混合的工序；工序(2)：将N末端及C末端未保护的氨基酸或肽与三烷基甲硅烷基化剂混合的工序；及将工序(1)中得到的产物与工序(2)中得到的产物混合的工序。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN113614061A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN113614061A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN113614061A3</originalsourceid><addsrcrecordid>eNrjZFD1dQ3x8HdRcPMPUggI8ncJdfb0c1cIcA0I8XRxVXD29w3wD_Vz4WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hobGZoYmBmaGjsbEqAEAoW0jPQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD FOR PRODUCING PEPTIDE COMPOUND</title><source>esp@cenet</source><creator>ASAKA YUKIO ; KOBAYASHI YUTAKA ; TAKEUCHI HISAYUKI ; NAGAYA AKIHIRO ; TAGURI TOMONORI ; KURASAKI HARUAKI ; CARY DOUGLAS ROBERT ; MASUYA KEIICHI ; NEMOTO YOSHITAKA ; MATSUDA AYUMU ; HANDA MICHIHARU</creator><creatorcontrib>ASAKA YUKIO ; KOBAYASHI YUTAKA ; TAKEUCHI HISAYUKI ; NAGAYA AKIHIRO ; TAGURI TOMONORI ; KURASAKI HARUAKI ; CARY DOUGLAS ROBERT ; MASUYA KEIICHI ; NEMOTO YOSHITAKA ; MATSUDA AYUMU ; HANDA MICHIHARU</creatorcontrib><description>The present invention provides a method for producing a peptide containing an N-alkyl amino acid, the method comprising the following steps (1) to (3). Step (1): Mix an N-terminus protected amino acid or an N-terminus protected peptide with a carboxylic acid halide or a halogenated alkyl formate; step (2): mix an amino acid or peptide, in which the N-terminus and C-terminus are not protected, with a trialkyl silylating agent; and step (3): mix the product obtained in step (1) with the product obtained in step (2).
本发明提供含有N-烷基氨基酸的肽的制造方法,其包括下述工序(1)至(3)。工序(1)：将N末端保护氨基酸或N末端保护肽与羧酸卤化物或卤代甲酸烷基酯混合的工序；工序(2)：将N末端及C末端未保护的氨基酸或肽与三烷基甲硅烷基化剂混合的工序；及将工序(1)中得到的产物与工序(2)中得到的产物混合的工序。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211105&DB=EPODOC&CC=CN&NR=113614061A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211105&DB=EPODOC&CC=CN&NR=113614061A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ASAKA YUKIO</creatorcontrib><creatorcontrib>KOBAYASHI YUTAKA</creatorcontrib><creatorcontrib>TAKEUCHI HISAYUKI</creatorcontrib><creatorcontrib>NAGAYA AKIHIRO</creatorcontrib><creatorcontrib>TAGURI TOMONORI</creatorcontrib><creatorcontrib>KURASAKI HARUAKI</creatorcontrib><creatorcontrib>CARY DOUGLAS ROBERT</creatorcontrib><creatorcontrib>MASUYA KEIICHI</creatorcontrib><creatorcontrib>NEMOTO YOSHITAKA</creatorcontrib><creatorcontrib>MATSUDA AYUMU</creatorcontrib><creatorcontrib>HANDA MICHIHARU</creatorcontrib><title>METHOD FOR PRODUCING PEPTIDE COMPOUND</title><description>The present invention provides a method for producing a peptide containing an N-alkyl amino acid, the method comprising the following steps (1) to (3). Step (1): Mix an N-terminus protected amino acid or an N-terminus protected peptide with a carboxylic acid halide or a halogenated alkyl formate; step (2): mix an amino acid or peptide, in which the N-terminus and C-terminus are not protected, with a trialkyl silylating agent; and step (3): mix the product obtained in step (1) with the product obtained in step (2).
本发明提供含有N-烷基氨基酸的肽的制造方法,其包括下述工序(1)至(3)。工序(1)：将N末端保护氨基酸或N末端保护肽与羧酸卤化物或卤代甲酸烷基酯混合的工序；工序(2)：将N末端及C末端未保护的氨基酸或肽与三烷基甲硅烷基化剂混合的工序；及将工序(1)中得到的产物与工序(2)中得到的产物混合的工序。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD1dQ3x8HdRcPMPUggI8ncJdfb0c1cIcA0I8XRxVXD29w3wD_Vz4WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hobGZoYmBmaGjsbEqAEAoW0jPQ</recordid><startdate>20211105</startdate><enddate>20211105</enddate><creator>ASAKA YUKIO</creator><creator>KOBAYASHI YUTAKA</creator><creator>TAKEUCHI HISAYUKI</creator><creator>NAGAYA AKIHIRO</creator><creator>TAGURI TOMONORI</creator><creator>KURASAKI HARUAKI</creator><creator>CARY DOUGLAS ROBERT</creator><creator>MASUYA KEIICHI</creator><creator>NEMOTO YOSHITAKA</creator><creator>MATSUDA AYUMU</creator><creator>HANDA MICHIHARU</creator><scope>EVB</scope></search><sort><creationdate>20211105</creationdate><title>METHOD FOR PRODUCING PEPTIDE COMPOUND</title><author>ASAKA YUKIO ; KOBAYASHI YUTAKA ; TAKEUCHI HISAYUKI ; NAGAYA AKIHIRO ; TAGURI TOMONORI ; KURASAKI HARUAKI ; CARY DOUGLAS ROBERT ; MASUYA KEIICHI ; NEMOTO YOSHITAKA ; MATSUDA AYUMU ; HANDA MICHIHARU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113614061A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>ASAKA YUKIO</creatorcontrib><creatorcontrib>KOBAYASHI YUTAKA</creatorcontrib><creatorcontrib>TAKEUCHI HISAYUKI</creatorcontrib><creatorcontrib>NAGAYA AKIHIRO</creatorcontrib><creatorcontrib>TAGURI TOMONORI</creatorcontrib><creatorcontrib>KURASAKI HARUAKI</creatorcontrib><creatorcontrib>CARY DOUGLAS ROBERT</creatorcontrib><creatorcontrib>MASUYA KEIICHI</creatorcontrib><creatorcontrib>NEMOTO YOSHITAKA</creatorcontrib><creatorcontrib>MATSUDA AYUMU</creatorcontrib><creatorcontrib>HANDA MICHIHARU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ASAKA YUKIO</au><au>KOBAYASHI YUTAKA</au><au>TAKEUCHI HISAYUKI</au><au>NAGAYA AKIHIRO</au><au>TAGURI TOMONORI</au><au>KURASAKI HARUAKI</au><au>CARY DOUGLAS ROBERT</au><au>MASUYA KEIICHI</au><au>NEMOTO YOSHITAKA</au><au>MATSUDA AYUMU</au><au>HANDA MICHIHARU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR PRODUCING PEPTIDE COMPOUND</title><date>2021-11-05</date><risdate>2021</risdate><abstract>The present invention provides a method for producing a peptide containing an N-alkyl amino acid, the method comprising the following steps (1) to (3). Step (1): Mix an N-terminus protected amino acid or an N-terminus protected peptide with a carboxylic acid halide or a halogenated alkyl formate; step (2): mix an amino acid or peptide, in which the N-terminus and C-terminus are not protected, with a trialkyl silylating agent; and step (3): mix the product obtained in step (1) with the product obtained in step (2).
本发明提供含有N-烷基氨基酸的肽的制造方法,其包括下述工序(1)至(3)。工序(1)：将N末端保护氨基酸或N末端保护肽与羧酸卤化物或卤代甲酸烷基酯混合的工序；工序(2)：将N末端及C末端未保护的氨基酸或肽与三烷基甲硅烷基化剂混合的工序；及将工序(1)中得到的产物与工序(2)中得到的产物混合的工序。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN113614061A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | METHOD FOR PRODUCING PEPTIDE COMPOUND |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T18%3A50%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ASAKA%20YUKIO&rft.date=2021-11-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN113614061A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |