Method for inducing human placental mesenchymal stem cells to differentiate into hepatocytes in vitro and composition containing schisandrin B

The invention discloses a method for inducing human placenta mesenchymal stem cells to differentiate into hepatocytes in vitro. Schisandrin B is added in a hepatocellular-like induction stage, the effect of inducing the human placenta mesenchymal stem cells to differentiate into the hepatocytes with functions can be effectively improved, the used stem cells are the human placenta mesenchymal stem cells, and are rich in source, convenient to extract, clear in induction composition component and simple in induction operation, and the method has industrialization and commercialization prospects. 本申请公开一种体外诱导人胎盘间充质干细胞分化为肝细胞的方法，通过在类肝细胞化诱导阶段起加入五味子乙素，能有效提高人胎盘间充质干细胞诱导分化为具有功能性的肝细胞的效果，且使用的干细胞为人胎盘间充质干细胞，其来源丰富、提取方便，诱导组合物成分明确、诱导操作简单，具有工业化和商业化的前景。