Preparation method of water-soluble antibacterial quaternized chitosan/Ag nano composite microspheres

The invention discloses a preparation method of a water-soluble antibacterial quaternized chitosan/Ag nano composite microsphere. The method comprises the following steps: carrying out surface amino functionalization modification on Ag nano particles, and carrying out ultrasonic treatment to prepare a uniform Ag nano particle dispersion liquid; adjusting the mass ratio of 2,3-epoxypropyl trimethyl ammonium chloride to chitosan to obtain quaternized chitosan; dissolving a non-polar emulsifier solution, hydrophilic metal salt and quaternized chitosan in the amino-modified Ag nanoparticle aqueous dispersion liquid, and pre-emulsifying to obtain a crude emulsion; and after ice-bath ultrasonic treatment, dropwise adding a cross-linking agent, and reacting under the protection of nitrogen to prepare the water-soluble antibacterial quaternized chitosan/Ag nano composite microspheres. According to the quaternized chitosan/Ag nano composite microspheres and the preparation method thereof disclosed by the invention, a