Soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of soluble microneedle patch

The invention relates to a soluble microneedle patch for targeted diagnosis and treatment of skin diseases and preparation of the soluble microneedle patch, and belongs to the technical field of biological medicines. The patch comprises a base and polymer needle bodies, the polymer needle bodies are located on the base in an array mode, polymers forming the polymer needle bodies can be dissolved in water, and nano-drug particles are dispersed on the needle point parts of the polymer needle bodies. The preparation method comprises the following steps: treating a microneedle array female die by using oxygen plasma, so that the surface of the microneedle array female die is hydrophilic; and dripping the nano-drug solution on the surface of the microneedle array female die for centrifugal treatment, injecting the water-soluble polymer solution into the microneedle array female die, vacuumizing, drying, and stripping the microneedles from the female die to obtain the microneedle patch. The synthesized microneedle