Indocyanine green composite nanoparticle as well as preparation method and application thereof

The invention discloses an indocyanine green composite nanoparticle as well as a preparation method and application thereof, and the principle is as follows: albumin and manganese dioxide are used for loading indocyanine green into the nanoparticle through a mild reverse biomineralization method to obtain the indocyanine green composite nanoparticle which is abbreviated as ICG (at) BSA (at) MnO2. Compared with a traditional potassium permanganate-biomineralization method, the stability of a drug structure can be obviously protected, most alkaline drugs can be effectively loaded, and cell animal experiments also verify the anti-tumor effect of the nanoparticles. 本发明公开一种吲哚青绿复合纳米粒子及其制备方法与应用，其原理是利用白蛋白，将二氧化锰通过温和地反向生物矿化方法把吲哚青绿装载到纳米粒子中，得到吲哚青绿复合纳米粒子，其简写为ICG@BSA@MnO2；相较于传统的高锰酸钾-生物矿化方法，本发明可以明显的保护药物结构的稳定，并且可以有效装载大部分的碱性药物，细胞动物实验也验证了此纳米粒子在抗肿瘤方面的作用。