Intermediate, synthesis and application of vaccine adjuvant MPLA

The invention discloses an intermediate, synthesis and application of a vaccine adjuvant MPLA. According to the intermediate provided by the invention, an allyl phosphate ligand is used as a phosphate group source in MPLA, and Nap is used as a protecting group, so that removal is convenient in subsequent operation; the synthesis route of the intermediate is short, and the total yield is obviously increased. A basis is provided for synthesis and amplification of MPLA. 本发明公开了一种疫苗佐剂MPLA的中间体、合成及应用。本发明提供的中间体以烯丙基磷酸配体为MPLA中磷酸基团来源，Nap为保护基，在后续操作中均可以方便的除去；合成的该中间体路线短，总收率明显增加。为MPLA的合成和放大提供了基础。