Preparation method of porous microspheres, microsphere embolization agent obtained by preparation method and application of same
The invention relates to a porous microsphere preparation method, which comprises: S1, dissolving an ethylene glycol polymer and polyvinylpyrrolidone in purified water, stirring to dissolve, adding N,N-methylene acrylamide, and adding ethyl methacrylate to dissolve so as to provide a water phase; s2...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a porous microsphere preparation method, which comprises: S1, dissolving an ethylene glycol polymer and polyvinylpyrrolidone in purified water, stirring to dissolve, adding N,N-methylene acrylamide, and adding ethyl methacrylate to dissolve so as to provide a water phase; s2, adding liquid paraffin into petroleum ether, and adding tetramethylethylenediamine to provide an oil phase; s3, under stirring, dropwise adding the water phase into the oil phase, rapidly stirring the mixutre for 1-4 hours, heating the mixutre to 40-60 DEG C, continuously stirring the mixutre for 2-5 hours, and filtering the mixutre to obtain the porous microspheres. The invention also relates to the microsphere embolization agent obtained by the method and application thereof. According to the preparation method of the porous microspheres, the porous microspheres are obtained by dropwise adding the water phase into the oil phase. The product is of a micron-sized spherical structure with a porous structure on the |
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